Toronto police said emergency crews were called just after 2 p.m. to the area of Queen Street West and Brock Avenue, which is west of Dufferin Street.
Police said there was a two-car crash and one of the cars jumped the curb, while the other went into a building.
A pedestrian was struck in the incident, police said, and serious injuries were reported.
Toronto paramedics said a man was taken to a trauma centre with serious but non-life-threatening injuries.
A second patient was taken to a local hospital with minor injuries, paramedics said.
Roads were closed in the area.
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